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Cox, ASHG 2017 President Of all science, human genetics is no doubt most cognizant of the value of diversity.

It seems like a particularly important time to remind ourselves of the value of having a really deep understanding of the all of the genetic diversity in human populations and how local adaptations to specific environments, past and present, now reach through to affect our risk to what is often termed diseases of western diet and lifestyle. Technology advances are rapidly expanding our ability to catalog human variation, and a host of new kinds of -omics data and computational methods provide an ever better foundation for understanding how this genetic variation affects the entire spectrum of human phenotypes.

New observations inevitably lead to a reconsideration of what we think we know, and new kinds of data expand the kinds of questions we can ask, and I will explore both of these facets with reference to balancing selection. Mc Kusick Leadership Award recognizes individuals whose professional achievements have fostered and enriched the development of human genetics as well as its assimilation into the broader context of science, medicine, and health.

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2/ An atlas of 8,342 mosaic structural variants reveals genetic drivers of clonal hematopoiesis.